How MUSC Safeguards Critical 340B Program Eligibility with a 100% Audit of >3M Pharmacy Claims
Medical University of South Carolina (MUSC)
35,000+
East Coast
340B Compliance Audit
100% Audit Coverage for Eligible 340B Claims
MUSC leverages the Plenful platform to automate their 340B compliance audits. Plenful’s initial scope covered an important subset of MUSC’s claims, specifically those from contract and in-house pharmacies. Subsequent to implementation, auditors went from spotting just a few issues per month to confidently addressing dozens. Convinced by the efficiency gains, MUSC quickly expanded the audit to include all mixed-use claims, increasing Plenful’s audit coverage to 100% of their 340B claims.
Protecting MUSC’s 340B Program and Lowering Their HRSA Risk Score
Since going live in January 2025, Plenful has audited more than 3 million claims for MUSC. Plenful’s intuitive task management dashboard makes it easy for MUSC’s team to review and reconcile flagged claims as they surface. This 100% claim audit would be virtually impossible to replicate manually. MUSC estimates it would take over a hundred team members to match the coverage and precision of Plenful’s automation. Plenful unlocks significant capacity gains for their lean team.
Increased Reporting Visibility Puts MUSC in Control of 340B Results and Impact
Plenful's analytics capabilities have strengthened MUSC's preparedness for HRSA audits. Plenful comprehensively audits claims previously approved by other systems and flags those missing sufficient eligibility justification, alerting MUSC's team to take targeted corrective action. The value the team is receiving expands beyond ROI to reduced levels of stress and uncertainty about the strength of their 340B compliance posture.
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340B Program Leaders
Medical University of South Carolina (MUSC)
Introduction
MUSC Safeguards Critical 340B Program Eligibility With Plenful's 100% Audit of >3M Pharmacy Claims
The Medical University of South Carolina (MUSC) is a nationally ranked academic medical center headquartered in Charleston, SC. With 16 hospitals, over 2,700 beds, and more than 34,000 employees, MUSC delivers advanced patient care while serving a large, diverse population.
Five of MUSC’s hospitals are 340B-eligible Disproportionate Share Hospital (DSH) facilities, helping the system reinvest savings into services for underserved communities.
Challenge
Managing 340B Compliance Across Millions of Complex Claims
As MUSC’s 340B program expanded to over 350,000 claims per month, its lean three-person audit team worked to build and maintain a strong compliance process. Their existing workflows, though well-established, couldn’t scale to the volume and complexity of the claims. The team faced heightened risk exposure, with limited visibility into potential errors across both contract and mixed-use pharmacy claims.
John David Scheper, System Director of 340B Program Operations, described the challenge as "looking for a needle in a haystack"; a small subset of issues amongst their millions of annual claims could easily expose the system to compliance risk.
MUSC's leadership saw this growth as an opportunity to leverage technology to ensure the sustainability of their 340B program and the patient care it funds. Team member transitions and siloed data environments further complicated audit continuity and accuracy. They needed a solution to scale auditing capacity, improve claim review accuracy, and reduce operational risk.
Solution
Automated, System-Wide Compliance Audits with Full Visibility and Control
MUSC partnered with Plenful to automate their 340B compliance audits, beginning with contract and in-house pharmacy claims. Subsequent to implementation, auditors went from spotting just a few issues per month to confidently addressing dozens. Convinced by the efficiency gains, MUSC quickly expanded the partnership to include all mixed-use claims, growing Plenful’s audit coverage to 100% of their 340B claims.
Plenful integrates with MUSC’s data ecosystem, ingesting and normalizing claims data from Epic, MacroHelix, Walgreens, Wellpartner, and Verity, with minimal IT lift. The platform also uses a Plenful-hosted SFTP for daily and monthly data exchanges. From there, Plenful’s agentic workflow engine continuously reviews every 340B claim and flags exceptions in a user-friendly task queue, enabling MUSC's staff to take targeted, high-impact action.
No more searching for a needle in a haystack, with Plenful, they're using a magnet. Plenful also provides real-time executive dashboards, unlocking insights across departments and strengthening MUSC’s compliance posture ahead of future HRSA audits.
Results
Protecting MUSC’s 340B Program and Lowering Their HRSA Risk Score
To date, the Plenful partnership has unlocked real value for the MUSC team:
- 100% compliance audit of >3 million 340B claims, scaling auditor capacity
- Expanded to full audit coverage in under one week, including mixed-use claims, a testament to Plenful's flexibility and impact
- Achieved >4.5x ROI by amplifying auditor productivity and strengthening compliance posture
- Enabled real-time audit performance tracking and cross-departmental alignment through executive dashboards