Manual audit processes make it nearly impossible for 340B programs to scale. Teams are often limited to spot audits—leaving thousands of claims unchecked and exposing programs to compliance risk. Misclassified claims, inconsistent data, and messy audit trails only compound the problem. Without a centralized platform to track, search, and validate claims activity, teams remain anxious about audit readiness and the potential for findings that could jeopardize their program eligibility.

Siloed data and rigid eligibility logic create blind spots that hide millions in potential 340B savings. Referral data is often scattered across disparate systems, making it a “needle in a haystack” to find eligible claims. The result: missed opportunities, inefficiencies, and a lack of clear visibility into program performance. Most Covered Entities don’t have the bandwidth or analytics infrastructure to uncover these insights—let alone act on them.

New and evolving policies—like the 340B Rebate Model Pilot and Medicare Drug Price Negotiation Program—are reshaping the 340B landscape. These changes will require teams to rapidly adapt operational processes, reporting structures, and financial oversight models. The organizations that succeed will be those that modernize early—using automation to stay compliant, nimble, and financially resilient amid growing regulatory complexity.